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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIAS1 All Species: 16.06
Human Site: S624 Identified Species: 35.33
UniProt: O75925 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75925 NP_057250.1 651 71836 S624 S S N S L R E S H S H T V T N
Chimpanzee Pan troglodytes XP_523109 766 83908 S739 S S N S L R E S H S H T V T N
Rhesus Macaque Macaca mulatta XP_001082800 642 70843 H616 S N S L R E S H S H T V T N R
Dog Lupus familis XP_535524 651 71773 S624 S S N S L R E S H S H T V A N
Cat Felis silvestris
Mouse Mus musculus O88907 651 71599 S624 S S N S L R E S H G H G V A S
Rat Rattus norvegicus O70260 628 68345 S602 S I V A P G S S L R E G H G G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516107 756 82793 S723 S N S S L V S S N S L R E N H
Chicken Gallus gallus NP_001026627 564 62782 D538 H M T P M P Y D L Q G L D F F
Frog Xenopus laevis NP_001079161 649 71676 E623 V S S N S L R E S H N A P S R
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q94361 793 89556 G717 Q T P T S Q Y G Y S P M I N Q
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q680Q4 884 97015 G652 D P H S I A G G S S G L G L F
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 84.9 98.6 99.6 N.A. 98 58.6 N.A. 82.2 82.9 87 N.A. N.A. N.A. N.A. 24 N.A.
Protein Similarity: 100 84.9 98.6 99.8 N.A. 98.7 72 N.A. 84.2 85 94.3 N.A. N.A. N.A. N.A. 40.9 N.A.
P-Site Identity: 100 100 6.6 93.3 N.A. 73.3 13.3 N.A. 33.3 0 6.6 N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 100 20 93.3 N.A. 80 20 N.A. 60 6.6 33.3 N.A. N.A. N.A. N.A. 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 20 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 35.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 0 10 0 0 0 0 0 10 0 19 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 0 0 0 0 10 0 0 0 0 10 0 0 % D
% Glu: 0 0 0 0 0 10 37 10 0 0 10 0 10 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 19 % F
% Gly: 0 0 0 0 0 10 10 19 0 10 19 19 10 10 10 % G
% His: 10 0 10 0 0 0 0 10 37 19 37 0 10 0 10 % H
% Ile: 0 10 0 0 10 0 0 0 0 0 0 0 10 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 10 46 10 0 0 19 0 10 19 0 10 0 % L
% Met: 0 10 0 0 10 0 0 0 0 0 0 10 0 0 0 % M
% Asn: 0 19 37 10 0 0 0 0 10 0 10 0 0 28 28 % N
% Pro: 0 10 10 10 10 10 0 0 0 0 10 0 10 0 0 % P
% Gln: 10 0 0 0 0 10 0 0 0 10 0 0 0 0 10 % Q
% Arg: 0 0 0 0 10 37 10 0 0 10 0 10 0 0 19 % R
% Ser: 64 46 28 55 19 0 28 55 28 55 0 0 0 10 10 % S
% Thr: 0 10 10 10 0 0 0 0 0 0 10 28 10 19 0 % T
% Val: 10 0 10 0 0 10 0 0 0 0 0 10 37 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 19 0 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _